Vitamins and Minerals Reference
Explore essential micronutrients, clinical deficiency indicators, biochemical cofactors, and optimal whole-food bioavailability strategies.
TL;DR
- Consume fat-soluble
vitaminsAdekalongside dietary lipids to facilitate intestinal micellar absorption. - Incorporate bioavailable
chelatedMineralsto support hundreds of critical enzymatic cellular reactions. - Screen annual blood
calcidiolLevelsto prevent silent subclinical vitamin D deficiencies.
Fat-Soluble Vitamin Physiology
Vitamin A (Retinoids)Sustain retinal rhodopsin synthesis for night vision and regulate mucosal epithelial gene expression.
const rdaRetinoids = "700mcg to 900mcg RAE";
// Preformed in liver and eggs; carotenoids in plantsVitamin D3 (Calcitriol)Facilitate active intestinal calcium absorption and modulate innate and adaptive immune cell signaling.
const dailyD3 = "1000IU to 4000IU daily";
// Target serum 25(OH)D: 40 to 60 ng/mLVitamin E (Tocopherols)Incorporate into cellular lipid bilayers to terminate free-radical-induced lipid peroxidation cascades.
const rdaTocopherol = "15mg alpha-tocopherol";
// Abundant in raw almonds, sunflower seeds, and oilsVitamin K (K1 and K2)Activate hepatic prothrombin for blood coagulation and activate osteocalcin for arterial calcification prevention.
const forms = {
K1: "leafy greens for clotting",
K2: "natto and dairy for bone-matrix binding"
};Water-Soluble Vitamin Spectrum
Vitamin B12 (Cobalamin)Catalyze methionine synthase for DNA synthesis and maintain myelin sheath sheath nerve insulation.
const dailyB12 = "2.4mcg daily RDA";
// Mandatory supplement for strict vegan dietsVitamin B9 (Folate)Transfer one-carbon units during purine synthesis and prevent fetal neural tube developmental defects.
const dailyFolate = "400mcg to 600mcg DFE";
// Found abundantly in dark leafy greens and legumesVitamin B6 (Pyridoxine)Serve as essential cofactor for over 100 enzymatic reactions in protein metabolism and neurotransmitter synthesis.
const dailyB6 = "1.3mg to 1.7mg daily";
// Avoid megadoses > 100mg to prevent neuropathyVitamin C (Ascorbate)Act as an indispensable electron donor for collagen synthesis enzymes and neutralize aqueous free radicals.
const dailyAscorbate = "75mg to 90mg minimum";
// Rich in bell peppers, kiwi, broccoli, and citrusEssential Mineral Matrix
Elemental MagnesiumAct as a required cofactor for over 300 enzymatic reactions, ATP energy transport, and muscle relaxation.
const dailyMagnesium = "310mg to 420mg elemental";
// Sourced from pumpkin seeds, cacao, and spinachChelated IronForm the central coordinating atom in heme proteins responsible for tissue oxygen delivery in erythrocytes.
const forms = {
heme: "high bioavailability in meat/fish",
nonHeme: "pair with vitamin C for absorption"
};Elemental ZincFacilitate zinc finger protein folding, stimulate wound healing, and govern DNA polymerase fidelity.
const dailyZinc = "8mg to 11mg elemental zinc";
// Sourced from oysters, beef, and pumpkin seedsBioavailable CalciumProvide mineral density to hydroxyapatite bone crystal matrix and govern skeletal muscle excitation-contraction.
const dailyCalcium = "1000mg to 1200mg daily";
// Sourced from dairy, sardines with bones, and greensNutrient Synergy and Antagonism
D3 and K2 SynergyVitamin D3 increases intestinal calcium absorption while vitamin K2 activates matrix-GLA proteins to deposit calcium into bone.
const boneSynergy = "D3 + K2 + Calcium";
// Prevents soft tissue and arterial calcificationIron and Vitamin CAscorbic acid reduces ferric iron to the more soluble ferrous iron state, tripling intestinal non-heme absorption.
const ironPairing = "lentils + red bell peppers";
// Overcomes phytate inhibitory bindingZinc and Copper BalanceHigh-dose supplemental zinc upregulates intestinal metallothionein which selectively traps copper, inducing anemia.
const ratio = "maintain 10:1 to 15:1 zinc to copper";
// Always balance supplemental zinc with copperTips
- Pair non-heme
plantIronwith ascorbic acid from citrus or bell peppers to enhance mineral absorption up to threefold. - Take fat-soluble
vitaminD3with the largest meal containing healthy lipids to maximize lymphatic absorption.
Warnings
- Vegans must supplement with active
cyanocobalaminB12 because plant foods contain biologically inactive pseudo-B12 analogues. - Chronic excessive
vitaminAintake from preformed retinoid supplements accumulates in hepatic tissue, causing severe hepatotoxicity.
In Practice
A 29-year-old vegetarian graphic designer resolves debilitating lethargy and brain fog by correcting subclinical micronutrient deficiencies.
Rachel suffered from profound fatigue, cold intolerance, and brittle nails despite sleeping eight hours nightly. A comprehensive blood panel revealed a serum ferritin of 9 ng/mL and vitamin D of 18 ng/mL.
- Initiated 5000 IU vitamin D3 paired with 100mcg vitamin K2 daily with lunch.
- Supplemented 65mg elemental iron alongside 500mg vitamin C on an empty stomach.
- Started daily 500mcg sublingual methylcobalamin vitamin B12 supplementation.
- Incorporated dark leafy greens and raw pumpkin seeds into daily meals for magnesium.
Within eight weeks, Rachel's ferritin rose to 45 ng/mL, vitamin D hit 52 ng/mL, and her energy fully returned.
Subclinical micronutrient deficiencies profoundly impair cellular energy; targeted synergy pairings rapidly restore biochemical balance.
FAQ
Fat-soluble vitaminsAdek store in hepatic and adipose tissues for months, while water-soluble vitamins like B-complex and C excrete daily through renal pathways.
Synthesized cholecalciferol undergoes hepatic and renal hydroxylation into calcitriol, a secosteroid hormone that binds nuclear VDR receptors to regulate over 1,000 genes.
Subclinical ironDeficiency manifests as pallor, exertional dyspnea, and fatigue, whereas magnesium deficiency typically presents as muscle twitches, cramps, and restless sleep.